Molecular recognition of flunarizine dihydrochloride and β-cyclodextrin inclusion complex by NMR and computational approaches

Molecular recognition of flunarizine dihydrochloride and β-cyclodextrin inclusion complex by NMR and computational approaches

BACKGROUND Flunarizine dihydrochloride (FLN) is used in the prophylactic treatment of migraine, vertigo, occlusive peripheral vascular disease and epilepsy. Cyclodextrins (CDs) are chiral, truncated cone shaped macrocycles known for their inner hydrophobic and outer hydrophilic site. They form complexes with hydrophobic drug molecules and enhance the solubility and bioavailability of such compo...

NMR spectroscopic characterization of β- cyclodextrin inclusion complex with vanillin

Β-cyclodextrin Inclusion Complex of Curcumin

Formation of inclusion complex of curcumin with β-cyclodextrin ( β-CD) has been characterized by absorption and fluorescence spectroscopy. From temperature-dependent fluorescence measurements, the thermodynamic parameters ∆H and ∆S, for the complexation were estimated. Kinetics of binding was studied by stopped flow technique, from which the binding constants for inclusion complex was estimated...

Inclusion Complex of β - Cyclodextrin and Quercetin . Thermodynamic Approach

CSABA PAL RACZ1, ROXANA-DIANA PASCA1, SANTA SZABOLCS1, IRINA KACSO2, GHEORGHE TOMOAIA3, AURORA MOCANU1, OSSI HOROVITZ1, MARIA TOMOAIA-COTISEL1* 1Babes-Bolyai University of Cluj-Napoca, Faculty of Chemistry and Chemical Engineering, Department of Physical Chemistry, 11 Arany J. Str., 400028 Cluj-Napoca, Romania 2National Institute of Research and Development for Molecular and Isotopic Technologi...

Preparation and Evaluation of Silymarin β-cyclodextrin Molecular Inclusion Complexes

Silymarin is a hepatoprotective agent, having poor water solubility and oral absorption of about 23 - 47%, leading to low bioavailability of the drug. The aim of the present study is to improve the solubility and dissolution rate and in turn the hepatoprotective activity of the drug, by formulating its inclusion complex with beta (β)-cyclodextrin, using different methods. The phase solubility a...